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Fioricet Drug Interaction

Fioricet contains Butalbital, Acetaminophen, and caffeine.  A lot of other pain relievers contain Butalbital, Acetaminophen, and caffeine too.

Fioricet is a combination medication that is used to treat complex tension headaches when other medications have not been effective.

Fioricet is a combination medication used to treat migraines or severe headaches. Learn the uses, effects and how to use Fioricet safely.

What is Fioricet?

Fioricet is the brand name multi-ingredient medication that’s used to treat some types of headaches. It’s also available in generic form.
Fioricet contains:

  • butalbital 50mg
  • acetaminophen 300mg
  • caffeine 40mg

It’s FDA-approved to treat symptoms of a common type of headache known as tension headache but is also prescribed off-label for migraine.

Butalbital APAP Caffeine is used to treat tension headaches. Acetaminophen helps to decrease the pain from the headache. Caffeine helps increase the effects of acetaminophen. Butalbital is a sedative that helps to decrease anxiety and cause sleepiness and relaxation.

Butalbital APAP Caffeine has following side effects: Bloated or “gassy” feeling, dizziness or lightheadedness (mild), drowsiness (mild), nausea, vomiting, or stomach pain (occurring without other symptoms of overdose), Bleeding or crusting sores on lips, chest pain, fever with or without chills, hive-like swellings (large) on eyelids, face, lips, and/or tongue, muscle cramps or pain

Butalbital APAP Caffeine can not be taken for a long time, your body may get used to it so that larger amounts are needed to produce the same effects. This is called tolerance to the medicine. Also, butalbital may become habit-forming (causing mental or physical dependence) when it is used for a long time or in large doses. Physical dependence may lead to withdrawal side effects when you stop taking the medicine. In patients who get headaches, the first symptom of withdrawal may be new (rebound) headaches.

Gabapentin Neurontin is a good medicine for Migraine Prevention.

I can only list some common over the counter medicines that contain Acetaminophen:  Actifed, Alka-Seltzer, Plus Liquid Gels, Anacin, Cepacol, Contac, Coricidin, Dayquil, Dimetapp, Dristan, Excedrin, Feverall …

Some prescriptions that contain acetaminophen are: Ultrace, Fioricet, Oxycodone, Endocet, Tylox …

You also must know what drugs contain Butalbital:  Bupap, Phrenilin, Tencon, Cephadyn; Fioricet, Esgic, Esgic-Plus; Fioricet with Codeine, Floricet with Codeine, Phrenilin with Caffeine and Codeine; Axotal; Fiorinal, Butalbital Compound, Farbital, Idenal; Fiorinal with Codeine, Fiorinal with Codeine III, Ascomp with Codeine, Fiortal with Codeine.

When you take more than one pain killer, you must read very carefully about their components.  Never exceed the max dosage of acetaminophen and butalbital of all the medicines you are taking.   Normally All the packages sent to you have the drug introduction and doctor names and phone number.  Read the drug introduction very carefully and never share the medicines with your sisters, your brothers,  your parents, or any friends. Always do not let the children touch the medicines.

Please donot drink any alcohol (Ethanol) with your Fioricet Because Ethanol together with acetaminophen will cause serious side effects that affect your liver, and Ethanol together with Butalbital will cause side effects of dizziness, drowsiness.

Please don’t take herb while you are taking Fioricet. Even Vitamins will have some interaction with Fioricet.

Be honest to place the current medicines you are taking in the health questionnaire  form. The doctor will check whether you are OK to take Fioricet.  If they think your current drugs or herbs have some interaction with Fioricet, they will phone you to discuss the situation with you. So please always leave us the correct phone number. We will never call you to promote you anything.

Does Fioricet Interact with other Medications?

Severe Interactions

These medications are not usually taken together. Consult your healthcare professional (e.g., doctor or pharmacist) for more in formation.

  • SEDATIVE HYPNOTICS; ALCOHOL/SODIUM OXYBATE
  • XANTHINE DERIVATIVES/DIPYRIDAMOLE INJECTABLE

Serious Interactions

These medications may interact and cause very harmful effects. Consult your healthcare professional (e.g., doctor or pharmacist) for more in formation.

  • THEOPHYLLINE DERIVATIVES/CIMETIDINE
  • SELECTED ANTICONVULSANTS; BARBITURATES/CONTRACEPTIVES
  • STRONG CYP3A4 INDUCERS/ARIPIPRAZOLE LAUROXIL SUBMICRONIZED
  • SELECTED BARBITURATES/SELECTED ANTICONVULSANTS
  • SELECTED BARBITURATES/LAMOTRIGINE
  • SELECTED BARBITURATES/ESLICARBAZEPINE
  • SELECTED BARBITURATES/CARBAMAZEPINE
  • STRONG CYP3A4 INDUCERS/TRABECTEDIN
  • STRONG CYP3A4 INDUCERS/FLIBANSERIN
  • STRONG CYP3A4 INDUCERS/QUETIAPINE (> 150 MG)
  • STRONG CYP3A4 INDUCERS/TOLVAPTAN
  • STRONG CYP3A4 INDUCERS/SELECTED IMMUNOSUPPRESSANTS
  • ACETAMINOPHEN/SODIUM FUSIDATE
  • XANTHINE DERIVATIVES/ADENOSINE; HEXOBENDINE; REGADENOSON
  • BARBITURATES/METHOXYFLURANE
  • BARBITURATES/SELECTED ANTICOAGULANTS (VIT K ANTAGONISTS)

Moderate Interactions

These medications may cause some risk when taken together. Consult your healthcare professional (e.g., doctor or pharmacist) for more in formation.

  • SELECTED BARBITURATES; SELECTED HYDANTOINS/QUINIDINE
  • THEOPHYLLINE DERIVATIVES/LITHIUM
  • SELECTED ANTICONVULSANTS/ESTROGENS
  • SELECTED XANTHINE DERIVATIVES/FLUVOXAMINE
  • ACETAMINOPHEN/ISONIAZID
  • BARBITURATES/PHENOTHIAZINES
  • BARBITURATES/RIFAMPIN
  • ACETAMINOPHEN/BUSULFAN
  • ACETAMINOPHEN/SELECTED ANTICOAGULANTS
  • STRONG CYP3A4 INDUCERS/SELECTED ANTIPSYCHOTICS
  • SELECTED ANTICONVULSANTS/FELODIPINE
  • BARBITURATES/METRONIDAZOLE
  • BARBITURATES; HYDANTOINS/THEOPHYLLINE
  • CYP3A4 INDUCERS/DOXYCYCLINE
  • SELECTED CYP3A4 INDUCERS/CORTICOSTEROIDS
  • BARBITURATES/SELECTED BETA-BLOCKERS

Fioricet (acetaminophen / butalbital / caffeine) alcohol/food interactions

There are 6 alcohol/food interactions with Fioricet (acetaminophen / butalbital / caffeine)

Fioricet (acetaminophen / butalbital / caffeine) disease interactions

There are 25 disease interactions with Fioricet (acetaminophen / butalbital / caffeine) which include:

  • alcoholism
  • liver disease
  • acute alcohol intoxication
  • drug dependence
  • liver disease
  • porphyria
  • rash
  • respiratory depression
  • cardiac disease
  • hypertension
  • liver disease
  • PUD
  • PKU
  • adrenal insufficiency
  • depression
  • hematologic toxicity
  • osteomalacia
  • paradoxical reactions
  • cardiotoxicity
  • bipolar disorders
  • psychiatric disorders
  • psychotic disorders
  • renal dysfunction
  • seizure disorders
  • GERD

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