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6. your health conditions;
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15. high blood pressure;
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Gabapentin (Generic Neurontin ) is used to help control partial seizures (convulsions) in the treatment of epilepsy. This medicine cannot cure epilepsy and will only work to control seizures for as long as you continue to take it.
Gabapentin (Generic Neurontin ) is also used to manage a condition called postherpetic neuralgia, which is pain that occurs after shingles. It’s also taken for nerve pain. Nerve pain can be caused by different illnesses, including diabetes and shingles, or it can happen after an injury.
Gabapentin (Generic Neurontin ) works in the brain to prevent seizures and relieve pain for certain conditions in the nervous system. It is not used for routine pain caused by minor injuries or arthritis. Gabapentin is an anticonvulsant.
Occasionally, gabapentin (Generic Neurontin ) is used to prevent migraine headaches. Gabapentin (Neurontin) and pregabalin (Lyrica) are anticonvulsants and nerve pain medicines which have structural similarities to the inhibitory neurotransmitter GABA.
Gabapentin (Generic Neurontin ) is available only with your doctor’s prescription.
Gabapentin (Generic Neurontin ) is available in the following dosage forms:
Tablet, Extended Release, 24 HR
Gabapentin (Generic Neurontin ) was developed in 1993 and has indications for shingles (‘postherpetic neuralgia’) and partial-onset seizures. It has had a growing popularity in off-label uses for fibromyalgia, pain from a variety of causes, migraine, cocaine withdrawal, anxiety, and insomnia. A related compound, gabapentin encarbil (Horizant), is approved for shingles and restless leg syndrome. Pregabalin was developed in 2004 and is approved for nerve pain from diabetes and spinal cord injuries, fibromyalgia, and adjunctive treatment of partial-onset seizures. Although prescribed off-label for anxiety in the U.S., it is approved for this purpose in the U.K., where it is sometimes called the ‘new Valium’.
Gabapentin is an anticonvulsive medication which first discovered in the 1970s in Japan. Its original use was as a muscle relaxer and anti-spasmodic medication, but later, it was discovered the potential of the medication as anticonvulsive medication and as an adjunct to stronger anticonvulsants. Gabapentin is an anticonvulsant medication that got FDA approval for partial seizure therapy in 1993. Currently, gabapentin has FDA approval for:
Adjunctive therapy in the treatment of partial seizures with or without secondary generalization in patients over the age of 12 years old with epilepsy, and the pediatric population, 3 to 12 year-olds with a partial seizure
Moderate to severe restless leg syndrome (RLS) moderate to severe
It also has off-label use for neuropathic pain, fibromyalgia, bipolar disorder, postmenopausal hot flashes, essential tremors, anxiety, resistant depressant and mood disorders, irritable bowel syndrome (IBS), alcohol withdrawal, postoperative analgesia, nausea and vomiting, migraine prophylaxis, headache, interstitial cystitis, painful diabetic neuropathy, social phobia, generalized tonic-clonic seizures, pruritus (itching), insomnia, post-traumatic stress disorder (PTSD), and refractory chronic cough.
In one placebo-controlled, retrospective study that investigated the effects of gabapentin on about 700 patients with refractory partial seizure disorder, there was an improvement in overall well-being in patients. The effect prompted a controlled investigation of the drug in primary psychiatric conditions.
An important benefit of gabapentin is that there is no interaction with valproate, lithium, and carbamazepine. Also, gabapentin has minor side effects.
Gabapentin in Alcohol Withdrawal
For the first time, the DSM-V includes the diagnostic guidelines for alcohol dependency. There are a variety of severe diseases that result from or are influenced by alcohol dependence include stomach ulcers, liver issues, increased risk of heart disease, and neuropathy. Researchers assess that 3.8% of worldwide deaths result from direct or indirect effects of alcohol abuse.
While gabapentin’s mechanism of action is generally understood, it appears to be a logical pharmacologic option for treating issues involving the GABA receptor system. Gabapentin is a safe, readily available, and effective drug for alcohol-use disorder treatment, specifically for the abstinence maintenance phase. A 2014 trial bolstered the evidence base for gabapentin use in the treatment of alcohol use disorder. Results for insomnia and cravings, two symptoms of alcohol use disorder abstinence maintenance, demonstrated significant improvement with gabapentin pharmacotherapy. Gabapentin has also shown a statistical benefit when used as adjunctive therapy to naltrexone (the FDA-approved alcohol use disorder medication). It is also clear that higher doses of gabapentin, 1800 mg per day, seem to have a stronger effect on alcohol-use disorder abstinence maintenance. However, the trials investigating gabapentin as monotherapy have shown mixed results.
For gabapentin, unlike disulfiram and naltrexone, there is no need for hepatic dose adjustments. Gabapentin can also be used in patients whose renal function is below 20 mg/dl (although a dosing adjustment is needed).
In 2007, Melcolm and his team compared gabapentin to lorazepam. They concluded that there were significant reductions in self-reported sleep disturbance and daytime sleepiness in patients undergoing outpatient treatment for alcohol withdrawal.
A double-blind study investigated the use of 1200 mg/ per day gabapentin in alcohol use disorder. Specifically, the researchers found gabapentin to be superior to the benzodiazepine lorazepam in treating outpatients with moderate alcohol withdrawal. This outcome was measured by a lower chance of drinking and a superior, but clinically, similar alcohol withdrawal symptom reduction.
Gabapentin in the Treatment of Anxiety and Depression
Gabapentin is rarely prescribed for patients with only anxiety disorder but is commonly prescribed for patients with bipolar disorder to reduce anxiety levels. Clinicians can also use it for patients who have anxiety and depression. Since anxiety is a coping skill, there is no drug to treat anxiety, but the medications used for this purpose make it possible to live at the moment, giving patients a chance to undergo anxiety treatment with non-pharmaceuticals. Even though the studies show that gabapentin is ineffective in the treatment of bipolar disorder, a case-control study with 60 patients in an acute phase of mania had a significant reduction in symptoms of anxiety with lithium and 900 mg of gabapentin. In another study with 21, mixed-state patients refractory to mood stabilizers received gabapentin (up to 2000 mg per day) for eight weeks, and patients with depressive symptoms had significant improvement in their CGI-BP (Clinical Global Impression-Bipolar) scores.
A meta-analysis of 7 trials pointed to gabapentin’s greater efficacy versus placebo in generalized anxiety disorder (GAD), although the effect size was approximately 0.35 for mental anxiety symptoms. A study of 153 patients who responded to the initial treatment of 450 mg per day for maintenance treatment of social anxiety disorder.
There are no clinical studies on the effectiveness of gabapentin as monotherapy or adjunctive therapy in major depressive disorders. However, there are case reviews that show some patients with depression who are refractory to standard antidepressants but showed therapeutic improvement when using gabapentin as adjunctive therapy.
In a randomized, double-blind study, with 130 patients that had under eye surgery, a one-time dose of 600 mg gabapentin significantly reduced the perioperative anxiety compared to a placebo. However, there was no significant difference compared to melatonin.
Gabapentin in Non-Epilepsy Neuropathic Pain like Postherpetic Neuralgia
The FDA approved gabapentin for the management of postherpetic neuralgia in adults. Recently, gabapentin underwent systemic evaluation in the management of diabetic neuropathy. In 1998, Rowbotham and his research team concluded that in 229 postherpetic neuralgia patients, gabapentin had more significant pain reduction as early as two weeks after initiating the treatment. Furthermore, other measurements of mood, depression, anger-hostility, fatigue, and physical functioning, were more effectively managed with gabapentin compared to placebo.
During the same time, Backonja reviewed the effect of gabapentin in 165 diabetic neuropathy patients and showed the result that pain reduction in the gabapentin group is greater (as measured with an 11-point Likert scale) in comparison to the placebo group. And the results were significant from 2 weeks of initiation of therapy and stayed significant during the eight weeks of study. Patients in the treatment group also reported improvement in their quality of life. This medication was well tolerated in 67% of patients who received a maximum daily dosage of 3600 mg.
Gabapentin in Movement Disorders
Gabapentin is effective for many movement disorders, for example, amyotrophic lateral sclerosis (ALS), parkinsonism, and essential tremor. The study populations were not as large as neuropathic pain groups.
In 1996, Miller et al. treated 152 ALS patients randomly assigned to receive 2400 mg gabapentin per day compared to a placebo group. Results showed a slower decline in muscle strength in the treatment group.
In 1998, Pahwa et al. reviewed the efficacy of gabapentin in treating essential tremor in comparison to a placebo. The first 14 days of the study showed no difference between patients receiving 1800 mg gabapentin per day compared to placebo. But in 2000, Ondo did six weeks of research on a group of patients receiving up to 3600 mg gabapentin per day in contrast to the placebo, and patients demonstrated significant improvements in self-report scores for tremor, observed tremor scores, and daily activity improvement scores.
In 1997, Olson and his team performed a one-month double-blind, placebo-controlled evaluation of the efficacy of gabapentin in 19 patients with advanced parkinsonism who were suffering from rigidity and bradykinesia. The treatment group received a total daily dosage of 1200 mg gabapentin per day. The results in this group were superior to the placebo group in reducing rigidity and bradykinesia as measured by the United Parkinson Disease Rating Scale. In the treatment group, there was a significant reduction in tremors, which was independent.